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Charleston SC · Charleston County 157,665 residents Columbia SC · Richland County 144,788 residents North Charleston SC · Charleston County 126,005 residents Mount Pleasant SC · Charleston County 95,604 residents Rock Hill SC · York County 75,798 residents Greenville SC · Greenville County 74,371 residents Summerville SC · Dorchester County 52,625 residents Goose Creek SC · Berkeley County 50,352 residents Greer SC · Greenville County 46,316 residents Sumter SC · Sumter County 42,958 residents Florence SC · Florence County 40,923 residents Myrtle Beach SC · Horry County 40,535 residents Spartanburg SC · Spartanburg County 39,606 residents Hilton Head Island SC · Beaufort County 38,158 residents Fort Mill SC · York County 36,244 residents Bluffton SC · Beaufort County 36,146 residents Aiken SC · Aiken County 32,694 residents Anderson SC · Anderson County 30,937 residents Mauldin SC · Greenville County 29,746 residents Conway SC · Horry County 29,656 residents Simpsonville SC · Greenville County 28,078 residents Easley SC · Pickens County 27,001 residents North Augusta SC · Aiken County 26,395 residents Lexington SC · Lexington County 25,354 residents